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차 의과학대학교 세계적 권위 SCI급 우수 논문 게재 현황

차 의과학대학교에서 세계적 권위가 입증된 SCI(Science Citation Index)급 학술지에 게재된 우수 논문들을 소개합니다.

Changes in general and central fatness are associated with hepatocellular carcinoma: A Korean nationwide longitudinal study

개제 일
2021-12-26
주 저자
김미나(공동제1,교신): 분당차병원 내과
공동 저자
하연정: 분당차병원 내과, 전영은: 분당차병원 내과, 이주호: 분당차병원 내과, 황성규: 분당차병원 내과
학술지 명
International journal of cancer
인용 지수
7.396
Changes in general and central fatness are associated with hepatocellular carcinoma: A Korean nationwide longitudinal study





Mi Na Kim, Kyungdo Han, Juhwan Yoo, Yeonjung Ha, Young Eun Chon, Ju Ho Lee, Seong Gyu Hwang



International journal of cancer, 150(10):1587-1598. doi: 10.1002/ijc.33920




ABSTRACT



We investigated the impact of short-term changes in general and central fatness on the risk of hepatocellular carcinoma (HCC) in a large, population-based cohort. We screened 7 221 479 subjects who underwent health examinations provided by the National Health Insurance Service of South Korea in 2009 and 2011. In total, 6 789 472 subjects were included in the final analysis. General fatness was defined as a body mass index (BMI) ≥25 kg/m2 , and central fatness was defined as a waist circumference (WC) ≥90 cm in men and ≥85 cm in women. Subjects were classified according to the change in body fatness between 2009 and 2011, as follows: (a) persistent no fatness as no fatness in both 2009 and 2011, (b) reversed fatness as fatness in 2009, but no fatness in 2011, (c) incident fatness as no fatness in 2009, but fatness in 2011 or (d) persistent fatness as fatness in both 2009 and 2011. During a median 6.4-year follow-up, we documented 9952 HCC cases. Compared to subjects with a persistent no general fatness, the risk of HCC significantly increased in those with incident (adjusted hazard ratio [aHR] = 1.10, 95% confidence interval [CI] = 1.01-1.20) and persistent (aHR = 1.28, 95% CI = 1.23-1.34) general fatness. Compared to subjects with persistent no central fatness, those with incident and persistent central fatness showed a significantly increased risk of HCC (aHR = 1.19, 95% CI = 1.11-1.27 and aHR = 1.33, 95% CI = 1.26-1.40, respectively). Taken together, these findings indicate the importance of strategies for preventing and reversing body fatness to reduce the incidence of HCC.

Keywords: body fatness; body mass index; hepatocellular carcinoma; waist circumference.

- PMID: 34957574


- Fulltext: https://onlinelibrary.wiley.com/doi/10.1002/ijc.33920