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차 의과학대학교 세계적 권위 SCI급 우수 논문 게재 현황

차 의과학대학교에서 세계적 권위가 입증된 SCI(Science Citation Index)급 학술지에 게재된 우수 논문들을 소개합니다.

Development of a Nanohybrid Peptide Hydrogel for Enhanced Intervertebral Disc Repair and Regeneration

개제 일
주 저자
한인보(공동교신): 분당차병원 신경외과
공동 저자
학술지 명
ACS nano
인용 지수
Development of a Nanohybrid Peptide Hydrogel for Enhanced Intervertebral Disc Repair and Regeneration


Brian M. Conley, Letao Yang, Basanta Bhujel, Jeffrey Luo, Inbo Han, and Ki-Bum Lee


ACS Nano, 2023, 17, 4, 3750–3764, doi:10.1021/acsnano.2c11441



Effective therapeutic approaches to overcome the heterogeneous pro-inflammatory and inhibitory extracellular matrix (ECM) microenvironment are urgently needed to achieve robust structural and functional repair of severely wounded fibrocartilaginous tissues. Herein we developed a dynamic and multifunctional nanohybrid peptide hydrogel(NHPH) through hierarchical self-assembly of peptide amphiphile modified with biodegradable two-dimensional nanomaterials with enzyme-like functions. NHPH is not only injectable, biocompatible, and biodegradable but also therapeutic by catalyzing the scavenging of pro-inflammatory reactive oxygen species and promoting ECM remodeling. In addition, our NHPH method facilitated the structural and functional recovery of the intervertebral disc (IVD) after severe injuries by delivering pro-regenerative cytokines in a sustained manner, effectively suppressing immune responses and eventually restoring the regenerative microenvironment of the ECM. In parallel, the NHPH-enhanced nucleus pulposus cell differentiation and pain reduction in a rat nucleotomy model further validated the therapeutic potential of NHPH. Collectively, our advanced nanoscaffold technology will provide an alternative approach for the effective treatment of IVD
degeneration as well as other fibrocartilaginous tissue injuries.


KEYWORDS: nanohybrid peptide hydrogel; nanoscaffolds; advanced tissue engineering; growth and differentiation factor; intervertebral disc repair; disc degeneration.
-PMID: 36780291


-Fulltext: https://pubs.acs.org/doi/10.1021/acsnano.2c11441