Tailored antiplatelet therapy in stent assisted coiling for unruptured aneurysms: a nationwide registry study

 

Jun Seok Koh, Gyojun Hwang, Jung Cheol Park, Chang-Young Lee, Joonho Chung, Sang-Weon Lee, Hyon-Jo Kwon, Seong-Rim Kim, Dong-Hun Kang, Soon Chan Kwon, Sung-Tae Kim, Chul Hoon Chang, Dong-Kyu Jang, Jae Hyung Choi, Young Woo Kim, Bum-Tae Kim, Byoung Gook Shin, Seung Hoon You, Seung Young Chung, Junkyeung Ko, Tae Gon Kim, Seok-Mann Yoon, Jong Young Lee, Hyun Park, Jung Hyun Park, Jae-Hoon Cho, Hae-Won Koo, Jae Hoon Sung, Jinnie Rhee, Ho Gyun Shin; for KoNES Registry Investigators

Journal of neurointerventional surgery, jnis-2022-019571. doi: 10.1136/jnis-2022-019571

ABSTRACT

Background: Antiplatelet therapy, where regimens are tailored based on platelet function testing, has been introduced into neurointerventional surgery. This nationwide registry study evaluated the effect and safety of tailored antiplatelet therapy in stent assisted coiling for unruptured aneurysms compared with conventional therapy using a standard regimen.

Methods: This study enrolled 1686 patients in 44 participating centers who received stent assisted coiling for unruptured aneurysms between January 1, 2019 and December 31, 2019. The standard regimen (aspirin and clopidogrel) was used for all patients in the conventional group (924, 19 centers). The regimen was selected based on platelet function testing (standard regimen for clopidogrel responders; adding cilostazol or replacing clopidogrel with other thienopyridines (ticlopidine, prasugrel, or ticagrelor) for clopidogrel non-responders) in the tailored group (762, 25 centers). The primary outcome was thromboembolic events. Secondary outcomes were bleeding and poor outcomes (increase in modified Rankin Scale score). Outcomes within 30 days after coiling were compared using logistic regression analysis.

Results: The thromboembolic event rate was lower in the tailored group than in the conventional group (30/762 (3.9%) vs 63/924 (6.8%), adjusted OR 0.560, 95% CI 0.359 to 0.875, P=0.001). The bleeding event rate was not different between the study groups (62/762 (8.1%) vs 73/924 (7.9%), adjusted OR 0.790, 95% CI 0.469 to 1.331, P=0.376). Poor outcomes were less frequent in the tailored group (12/762 (1.6%) vs 34 (3.7%), adjusted OR 0.252, 95% CI 0.112 to 0.568, P=0.001).

Conclusion: Tailored antiplatelet therapy in stent assisted coiling for unruptured aneurysms reduced thromboembolic events and poor outcomes without increasing bleeding.

Keywords: Aneurysm; Stent.

- PMID: 36596671

- Fulltext: https://jnis.bmj.com/content/early/2023/01/03/jnis-2022-019571.long