전형적인 알레르기 증상으로 내원한 6세 미만 소아 환자에서 항원 감작 패턴: 단일 기관 연구
윤정원, 이상민, 김준환, 김나연, 백지현, 백혜성, 지혜미, 김형윤, 최선희, 김기은, 염혜영, 한만용, 김진택, 신윤호
Allergy asthma & respiratory disease, v.2 n.4 p.272-276, doi: 10.4168/aard.2014.2.4.272
ABSTRACT
Purpose:Population studies have reported that sensitization to inhalant allergens is rare in young children; however, most subjects in those studies had little or no symptoms or signs highly suggestive of allergic diseases. The aim of the present study was to assess the prevalence of sensitization to inhalant allergens in young children with symptoms and/or signs of allergic disease.
Methods:We analyzed the results of all specific IgE tests performed at our hospital laboratory in children younger than 6 years presenting with symptoms and/or signs highly suggestive of allergic diseases between 2008 and 2013. Specific IgE tests for Dermatophagoides pteronyssinus, Dermatophagoides farinae, Alternaria alternata, German cockroach, cat dander, egg white or egg yolk, milk, peanut, and soybean were performed on 295 children; a specific IgE concentration ≥0.35 or ≥0.2 IU/mL was considered positive. We also compared allergen sensitization rates using the two cutoff values.
Results:One hundred eighty-one children (61.4%) were positive to at least 1 allergen tested and 53 children (18.9%) were positive to at least 1 inhalant allergen when a specific IgE concentration ≥0.35 IU/mL was considered positive. The children were more likely to have asthma or allergic rhinitis when they were sensitized to any inhalant allergen, particularly house dust mites. The prevalence of sensitization to inhalant allergens increased with age (P<0.001). There was no significant difference in the prevalence of polysensitization among different age groups, but sensitization to both inhalant and food allergens significantly increased with age.
Conclusions:Our results suggest that specific IgE tests to common inhalant allergens, particularly the house dust mites, may be considered when performing blood screening tests for young children presenting with symptoms and/or signs of allergic diseases.
- Fulltext: http://www.aard.or.kr/Synapse/Data/PDFData/9993AARD/aard-2-272.pdf
